In a radical image update, Two For The Road presented a new-look, more liberated Audrey Hepburn, dressed in the height of sixties mod fashion. The offbeat film covered twelve years of a faltering marriage, with a revolutionary non-linear narrative jumping back and forth episodically. In a dramatic departure for Audrey, the script called for adultery, profanity, bikini frolics and even a nude bedroom scene with co-star Albert Finney. Unusual among Audrey's leading men, Finney was actually seven years her junior.

Co-stars and friends described a more relaxed Audrey on the set of Two For The Road, laughing and joking between takes. Biographer Ian Woodward quotes director Stanley Donen ....the Audrey I saw during the making of this film I didn't even know. She overwhelmed me. She was so free, so happy. I never saw her like that. So young! ...I guess it was Albie. Finney and Hepburn became close during filming, provoking the usual reports of an on-set romance. According to biographer Charles Higham, Finney said of their time together We got on immediately...With a woman as sexy as Audrey, you sometimes get to the edge where make-believe and reality are blurred. All that staring into each other's eyes... The time spent with Audrey is one of the closest I've ever had.

Many praised Audrey's performance as her best in years, and Audrey herself was proud of the movie, though she was recognised instead with an Oscar nomination for her performance in Wait Until Dark, which was released the same year.